Diminished Ovarian Reserve
Patients experiencing premature ovarian failure, early menopause or medical conditions that have damaged their eggs can experience low pregnancy rates due mostly to the internal cellular decline of the eggs. More specifically, a delicate organelle called the meiotic spindle is responsible for normal cell division needed for the embryo to form normally.
Age Related Infertility
In age related infertility, a dysfunctional meiotic spindle leads to errors in chromosome number resulting in “Aneuploidy,” defined as embryos with too many or too few numbers of chromosomes. Normally, 23 pairs of chromosomes carry the correct DNA information required for normal embryo development, while an abnormal number increasingly leads to failed implantation or pregnancy loss.
In these cases, the physician would recommend using frozen donor eggs from young, healthy women to achieve pregnancy.